Where did this come from?

Hemophilia, I understand. I get the genetics of it. I’m not quite sure if I mutated or if we’ve had it in the family all along, but at least I understand. I know that 1/3 of all cases are spontaneous mutations. My mom only had girls. My grandmother had 5 girls and 2 boys. My great grandmother had 3 girls and 1 boy. Of course, there should have been some carriers in there to have sons with it. But, I only have 2 boy cousins from biological aunts on my mom’s side. Again, a carrier should have shown up in there somewhere. My nephew doesn’t have it. My niece might  be a carrier, but she’s not been tested. So, it looks like the buck probably started with me. But I have the tools and to figure that out. It gives me an idea of how I ended up with two boys with hemophilia.

I don’t get type I diabetes. Here’s what I found on the American Diabetes Association website:

Type 1 Diabetes

In most cases of type 1 diabetes, people need to inherit risk factors from both parents. We think these factors must be more common in whites because whites have the highest rate of type 1 diabetes. Because most people who are at risk do not get diabetes, researchers want to find out what the environmental triggers are.

One trigger might be related to cold weather. Type 1 diabetes develops more often in winter than summer and is more common in places with cold climates. Another trigger might be viruses. Perhaps a virus that has only mild effects on most people triggers type 1 diabetes in others.

Early diet may also play a role. Type 1 diabetes is less common in people who were breastfed and in those who first ate solid foods at later ages.

In many people, the development of type 1 diabetes seems to take many years. In experiments that followed relatives of people with type 1 diabetes, researchers found that most of those who later got diabetes had certain autoantibodies in their blood for years before.

(Antibodies are proteins that destroy bacteria or viruses. Autoantibodies are antibodies ‘gone bad,’ which attack the body’s own tissues.)

Let’s break it down.

  • Need to inherit it from BOTH parents. Neither of us have any family history of diabetes in our families anywhere, that we are aware of. This explains why I was met with dumb founded stares every time I said we had no family history.
  • Triggers of cold weather or a mild virus. Well, we had the most mild winter ever this year. Well, almost. Certainly more wild than we’ve been accustomed to in Illinois. A virus? I guess it’s possible, but she never really showed anything. And I think triggers work in conjunction with the genetic factors anyway.
  • Early diet? Really??? Girl was breastfed until 19 months. Earlier than other kids weaned, but there were extenuating circumstances at that point. Besides, that should have been way long enough to reduce her risk. I did start solids earlier with her than some of the others. But even so, she was 6 months old. I only did it then because my pediatrician was kind of bullying me into it. Again, 6 months isn’t 6 weeks, which is when her older sister started cereal (20 years ago, doctors thought differently than today).
  • So that leaves us with the autoantibodies. My personal belief on this is they are caused by vaccines. Hannah was vaccinated until 6 or 9 months of age. Can’t remember exactly when her last shots were. When I was a kid, I seem to remember kids were diagnosed with diabetes in the 8-12 year old range. Now, it’s very common for it to happen at around age 1, and again in kindergarten. Huh. What’s happening around those ages? Oh, I know! Lots of shots. Yes, I realize that correlation is not causation. But just in case? Makes me glad we decided to stop vaccinating.

Ok. Off my soap box. I haven’t even really been researching long enough to have one. But I just feel so lost since I can’t trace this to its origins. I’m the kind of person who needs to know why for everything. In fact, I even got a talking to at work during orientation as a result. My preceptor thought I was criticizing their policies/procedures because I kept asking why and bringing up how previous employers had done things. It’s just my method and need to understand. I’ve never been one to follow blindly. My hematologist in Illinois can attest to this as well. I don’t really do anything “by the book” where hemophilia is concerned. I picked my own prophy schedule (we infuse 2x/wk instead of 3x/wk). I adamantly refused the hepatitis B vaccine for the boys (seriously. You can’t brag about how no one has acquired HIV or Hep B from factor products for 20 years, and then convince me I need to vaccinate against the risk of Hep B from factor products; and now, we use factor that never even touches human blood products).

Well, off to do more research. I have to get to the bottom of this.